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F351
The small molecule compound F351 (NCE), developed by the
Company as a non-steroid anti-fibrosis drug, has shown
strong efficacy for treating a broad range of fibrosis
diseases, especially in liver. Liver disease is the so-called
¡°National Disease¡± in China. 130 million people are affected
in China alone due to HBV pandemic. In two animal studies,
orally administered F351 significantly inhibited liver
fibrosis and showed high level of safety. Major biochemical
and pathological parameters associated with liver fibrosis
returned to normal level after drug treatment in two animal models tested. In direct
comparison with Chinese herb medicine that had shown efficacy
in human trials, F351 was proved to be superior potency.
F351 has low molecular weight, good solubility in water,
and easy method to synthesize.No toxicity is observed in animal models at very high dosage. IND is expected to be filed by the end of 2006..
F647
F647 is another anti-inflammatory small molecule compound
designed to combat acute lung injury (ALI). SARS virus
infection and lung cancer radiation therapy both cause
acute lung injury, and in many cases, directly lead to
patient death. With 300 million smokers in China alone,
lung cancer cases are on up-swing and account for half
of the whole world. In animal model studies, F647 showed
strong efficacy to protect animal against drug induced
lung damage and improved animal nutritional status. In May, 2005, the Company received Clinical Trial Permit from the Chinese State Food and Drug Administration. F647 is currently in multi-center Phase II clinical studies.
"GuBang" Biomaterial
"GuBang" is a new generation of nano-meter biomaterial developed under the support of the National "863" Hi-Tech Program since 2002. This product has the unique characters of high biocompatibility, good absorption rate, and promoting new bone growth. After clinical studies, the product has received "Medical Device Registration Certificate" from the Chinese State FDA in March, 2006. "GuBang" has inter-connected porous structure. It is ideal for controlled drug release if loaded with antibiotics or anti-cancer chemotherapeutic drugs.
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