F351 The small molecule compound F351 (NCE), developed by the Company as a non-steroid anti-fibrosis drug, has shown strong efficacy for treating a broad range of fibrosis diseases, especially in liver. Liver disease is the so-called “National Disease” in China. 130 million people are affected in China alone due to HBV pandemic. In two animal studies, orally administered F351 significantly inhibited liver fibrosis and showed high level of safety. Major biochemical and pathological parameters associated with liver fibrosis returned to normal level after drug treatment in two animal models tested. In direct comparison with Chinese herb medicine that had shown efficacy in human trials, F351 was proved to be superior potency. F351 has low molecular weight, good solubility in water, and easy method to synthesize.No toxicity is observed in animal models at very high dosage. IND is expected to be filed by the end of 2006..