F647
F647 is another anti-inflammatory small molecule compound designed to combat acute lung injury (ALI). SARS virus infection and lung cancer radiation therapy both cause acute lung injury, and in many cases, directly lead to patient death. With 300 million smokers in China alone, lung cancer cases are on up-swing and account for half of the whole world. In animal model studies, F647 showed strong efficacy to protect animal against drug induced lung damage and improved animal nutritional status. In May, 2005, the Company received Clinical Trial Permit from the Chinese State Food and Drug Administration. F647 is currently in multi-center Phase II clinical studies.

F351
The small molecule compound F351 (NCE), developed by the Company as a non-steroid anti-fibrosis drug, has shown strong efficacy for treating a broad range of fibrosis diseases, especially in liver. Liver disease is the so-called “National Disease” in China. 130 million people are affected in China alone due to HBV pandemic. In two animal studies, orally administered F351 significantly inhibited liver fibrosis and showed high level of safety. Major biochemical and pathological parameters associated with liver fibrosis returned to normal level after drug treatment in two animal models tested. In direct comparison with Chinese herb medicine that had shown efficacy in human trials, F351 was proved to be superior potency. F351 has low molecular weight, good solubility in water, and easy method to synthesize.No toxicity is observed in animal models at very high dosage. IND is expected to be filed by the end of 2006..

"GuBang" Biomaterial
Gu Bang is our first clinically tested product to reach the Chinese market following its regulatory approval from the Chinese SFDA in March 2006.
Gu Bang is a new type of synthetic bone biomaterial that is in a granule form. Containing the active ingredients hydroxyl apatite and calcium phosphate, Gu Bang is able to improve the outcome of complex fractures and bone cancer by replacing lost bone. Following implantation, the porous material provides an interconnecting microenvironment for host bone cells to develop during the bone's healing process. The material's strong biocompatibility means that the implant is gradually reabsorbed and that residual calcium and phosphate are used in the formation of new bone.
 
Gu Bang's synthetic composition mitigates the potential for rejection and poor adhesion, which is commonly associated with using bone harvested from human or animal cadavers.
 
© 2008 shanghaigenomics.com. All rights reserved