Shanghai Genomics (SG) has successfully established gene disruption platforms including siRNA and microRNA knockdowns. Using siRNA technology, SG has validated effective probes for the entire human kinome.

In combination with our effective DNA sub-cloning techniques, we are able to provide customized gene disruption services.

Services Include:

1)     Targeting Probe Design, Construction and Validation

2)     Transiently Targeting

3)     Long-term Targeting (Poly- or Mono- clonal Stable Cell Lines)

Gene disruption is a powerful method in biomedical research. Due to the low frequency of homological recombination, it is quite difficult to disrupt genes by direct genetic modification. Transcriptional knockdown by RNAi is an efficient way to over come these difficulties in a large number of R&D areas. Conditional RNAi is one of the best methods. SG has an experienced group of scientist in both RNAi techology (shRNA and miR-shRNA) and stable cell line development. In addition, SG owns a cell library, in which many ordinary ATCC sourced cell lines are readily available for use.