Shanghai Genomics (SG) has successfully established gene disruption platforms including siRNA and microRNA knockdowns. Using siRNA technology, SG has validated effective probes for the entire human kinome.

With high quality real-time PCR analysis, SG has successfully validated more than 2,800 shRNA probes for the human kinome. SG’s broad experience and maturity of experimental shRNA platforms ensure excellent RNAi services.

Services Include:

1)     shRNA Design and Vector Construction

2)     shRNA Probe Validation

3)     Knockdown of Selected Genes (Transient or Long-Term)

shRNA technology is one of the most powerful RNAi tools that is commonly used in biomedical research. When expressed in mammalian cells, the shRNA can be converted into siRNA. These siRNA molecules, initiate cleavage and degradation of specific mRNA molecules, providing either transient or long-term target gene suppression. Shanghai Genomics has successfully set up an efficient and high throughput platform to validate effective shRNAs for genes of interest.